Introduction
If a close male relative—your father, brother, or grandfather—has had prostate cancer, it’s natural to ask: “Is prostate cancer hereditary?” And if so, what can you do to reduce your risk?
Understanding the genetic and familial risk factors for prostate cancer is crucial in detecting the disease early or even preventing it altogether. While not all prostate cancers are inherited, family history does play a significant role.
In this guide, world-renowned prostate cancer expert Dr. David Samadi breaks down the science behind inherited risk, identifies who is most at risk, and outlines actionable steps to protect your prostate health.
What Is Prostate Cancer?
Prostate cancer develops when cells in the prostate gland begin to grow uncontrollably. It is the second most common cancer in men worldwide and primarily affects men over the age of 50.
While many prostate cancers grow slowly and are highly treatable when detected early, aggressive forms can spread quickly—especially in those with genetic predispositions.
Is Prostate Cancer Genetic?
Short Answer: Yes, it can be.
While most cases of prostate cancer are sporadic (occurring without a known cause), about 10%–15% of all cases are hereditary. This means they are linked to inherited genetic mutations passed down through families.
Key Genetic Risk Factors:
- BRCA1 and BRCA2 mutations: More commonly associated with breast and ovarian cancer, these mutations also increase prostate cancer risk—especially BRCA2, which is linked to more aggressive forms.
- HOXB13 mutation: A rare genetic change linked to early-onset prostate cancer in men with a strong family history.
- Lynch syndrome: A hereditary condition that increases the risk of several cancers, including prostate.
The Role of Family History in Prostate Cancer
A family history of prostate cancer significantly increases your risk. Risk levels vary depending on:
1. Number of Affected Relatives
- One first-degree relative (father or brother): 2x higher risk
- Two or more close relatives: 5–11x higher risk
2. Age at Diagnosis
- The younger the relative was when diagnosed (especially under 55), the higher your own risk.
3. Type of Relative
- First-degree (parents, siblings, children): Highest impact
- Second-degree (uncles, grandparents): Moderate impact
4. Ethnicity
- African-American men with family history face the highest hereditary risk and should be especially proactive.
“When a man tells me his father had prostate cancer at 52, I know we need to act early. Family history is one of the strongest indicators we have.” — Dr. David Samadi
How Genetics Influence Prostate Cancer
Genetic mutations can affect how cells repair DNA damage and regulate growth. In men with inherited mutations like BRCA2, prostate cells may be more likely to become cancerous.
These inherited mutations:
- Increase lifetime risk of developing prostate cancer
- Are often associated with early onset
- May result in more aggressive tumors
Genetic testing can help identify these mutations—especially in men with a strong family history or multiple relatives with cancer.
Should You Get Genetic Testing?
Dr. Samadi recommends genetic testing and counseling for:
- Men with multiple family members affected by prostate cancer
- Men with relatives who had BRCA1/2-related cancers (breast, ovarian, pancreatic)
- African-American men with prostate cancer in the family
- Anyone diagnosed with early-onset prostate cancer (<55)
Genetic counseling helps assess risk and determine if proactive steps, like earlier PSA screening, are needed.
Other Prostate Cancer Risk Factors
While genetics play a role, most prostate cancers are influenced by a combination of lifestyle, age, and environmental factors.
Non-Hereditary Risk Factors:
| Risk Factor | Details |
| Age | Risk increases significantly after age 50 |
| Race | African-American men have higher risk and more aggressive cancers |
| Diet | High-fat, processed foods linked to greater risk |
| Obesity | Associated with more aggressive forms |
| Hormonal levels | Elevated testosterone and DHT may play a role |
| Smoking | Increases the likelihood of advanced-stage cancer |
| Sedentary lifestyle | Lack of exercise may worsen outcomes |
“Genetics load the gun, but lifestyle pulls the trigger. The good news is: you can control many of the risk factors that impact prostate health.” — Dr. Samadi
How to Reduce Your Risk If Prostate Cancer Runs in Your Family
If you have a family history of prostate cancer, there’s no need to panic—but you do need a plan. Dr. Samadi recommends a combination of screening, lifestyle changes, and medical guidance.
1. Start PSA Screening Early
- Baseline test at age 40 if you have a family history
- Annual screenings afterward
- Monitor PSA velocity (how quickly PSA levels rise)
2. Follow a Prostate-Healthy Diet
- Load up on cruciferous vegetables (broccoli, kale, cauliflower)
- Add lycopene-rich foods (tomatoes, watermelon)
- Choose lean proteins (fish, poultry)
- Reduce red meat and dairy intake
- Avoid processed foods and added sugars
3. Exercise Regularly
- Aim for 30–45 minutes of moderate activity, 4–5 days a week
- Include strength training and cardiovascular exercises
4. Maintain a Healthy Weight
Obesity is linked to more aggressive prostate cancers and poorer outcomes.
5. Stay Informed
Know your PSA history, track symptoms, and communicate openly with your doctor. Knowledge is power.
What If You’re Diagnosed?
If screening or testing reveals prostate cancer, remember: early detection = better outcomes. Thanks to advances in robotic surgery, many men—especially those with genetic risks—can undergo minimally invasive procedures with faster recovery and better preservation of urinary and sexual function.
Dr. Samadi’s SMART Robotic Prostatectomy:
- Nerve-sparing for sexual function
- Minimally invasive, faster recovery
- Over 7,000 surgeries performed with top outcomes
- Concierge-style care from start to finish
“A family history doesn’t mean a death sentence. It just means we need to act sooner—and smarter.” — Dr. Samadi
FAQs About Genetic Risk and Prostate Cancer
Is prostate cancer inherited from the mother or father?
Both sides of the family matter. Inherited mutations can come from either parent.
What age should I start screening if my father had prostate cancer?
Start PSA screening at age 40, or 10 years younger than your relative’s diagnosis age—whichever comes first.
Can I do anything to prevent hereditary prostate cancer?
While you can’t change your genes, you can control lifestyle factors and catch cancer early through routine screening and proactive care.
Is genetic testing painful or complicated?
Not at all. It typically involves a saliva or blood test. Results can provide clarity and help guide your screening and prevention strategy.
Summary: Know Your Risk—Take Action Early
If you’re wondering, “Is prostate cancer genetic?”, the answer is: Yes, it can be. And if you have a family history, the time to act is now.
Here’s what you can do:
✅ Understand your family history
✅ Consider genetic testing
✅ Start PSA screening early
✅ Eat well, move more, and maintain a healthy weight
✅ Partner with a trusted expert like Dr. David Samadi
Early action can save your life—or the life of someone you love.
Schedule a Screening with Dr. David Samadi
If you have a family history of prostate cancer or simply want to understand your risk, don’t wait. Dr. Samadi and his team offer comprehensive consultations, genetic risk assessments, and personalized care plans tailored to your needs.
📍 Prostate Cancer 911
485 Madison Ave, 21st Floor
New York, NY 10022
📞 Call Today: (212) 365-5000
🌐 www.prostatecancer911.com
Take control of your health. Know your risk. Get screened early—with Dr. Samadi.