By Dr. David Samadi

Have you ever wondered if you, yourself, or other men know if their prostate cancer could be hereditary? What we know now is that approximately 5-10% of all types of cancers, including prostate cancer, can be hereditary, meaning specific cancer-related gene mutations can be passed down through generations. Thanks to ongoing research, we now understand that some prostate cancers are linked to changes in specific genes.

What are Genes and Mutations?

Every person born will inherit roughly 50% of their genes from each parent at conception. That means when the sperm from your father fertilizes the egg from your mother, half of your genetic makeup (eye and hair color, your height, etc.) is from your father and the other half from your mother.

DNA is the composition of our genes. DNA is a molecule encased inside every single cell of your body that contains the all-important genetic information necessary to tell your body how to develop and function. When a gene undergoes a mutation (a change in its DNA), it can sometimes lead to cancer. Some mutations are inherited and passed down from parents to their children. Mutations may arise as a result of smoking, exposure to UV rays, or other environmental factors.

In the context of prostate cancer, specific inherited genetic mutations can heighten one’s susceptibility. It is noteworthy that certain gene mutations associated with prostate cancer also exhibit links to other malignancies, including breast, colon, and pancreatic cancer. This means that even if prostate cancer doesn’t run in your family, a family history of these other cancers could still indicate a higher risk.

Why Consider Genetic Testing?

If you have a family history of any type of cancer, genetic testing can provide valuable insight. It’s a simple process that involves either a saliva or blood test. However, discussing your options with a doctor or genetic counselor is essential, as they can help you weigh the benefits and potential risks. While at-home genetic tests may seem convenient, they aren’t a substitute for clinical testing performed by healthcare professionals.

Who Should Get Tested?

Not everyone with prostate cancer needs genetic testing, but certain patients are encouraged to talk to their doctor about it. You may want to consider testing if:

  • You have high-risk, regional, or metastatic prostate cancer
  • You have Ashkenazi Jewish ancestry
  • There’s a family history of cancer-related gene mutations (such as BRCA1 or BRCA2)
  • You have a strong family history of prostate or other cancers

Genetic Testing and Treatment Options

Genetic testing isn’t just about understanding your risk—it can also play a critical role in treatment decisions, significantly if you have advanced prostate cancer. For instance, medications known as PARP inhibitors (like olaparib and rucaparib) are FDA-approved for men with specific genetic mutations, particularly those involved in DNA repair. These drugs can be game-changers for patients with metastatic castration-resistant prostate cancer.

Genetic Testing vs. Biomarker Testing

You may also hear about something called biomarker testing, which is different. While genetic testing looks at your inherited risk, biomarker testing focuses on the characteristics of the tumor itself, often using biopsy samples. From this information, doctors a clearer picture of the cancer’s behavior helping guide treatment.

Be Your Own Advocate

The more we learn about cancer treatment and how to save lives, the closer we are to understanding how to personalize our approach based on our genetic makeup. Knowing your family’s history of cancer and discussing genetic counseling with your doctor can be an empowering step. It’s all about taking control of your health, making informed and educated decisions, and being diligent about receiving the best possible care.

In summary, understanding your genetic risk can lead to targeted treatments and help you stay informed about your health. Don’t hesitate to discuss genetic testing with your doctor—it could make all the difference.

Dr. David Samadi is the Director of Men’s Health and Urologic Oncology at St. Francis Hospital in Long Island. He’s a renowned and highly successful board-certified Urologic Oncologist Expert and Robotic Surgeon in New York City, regarded as one of the leading prostate surgeons in the U.S., with a vast expertise in prostate cancer treatment and Robotic-Assisted Laparoscopic Prostatectomy.  Dr. Samadi is a medical contributor to NewsMax TV and is also the author of The Ultimate MANual, Dr. Samadi’s Guide to Men’s Health and Wellness, available online both on Amazon and Barnes & Noble. Visit Dr. Samadi’s websites at robotic oncology and prostate cancer 911.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

REQUEST AN APPOINTMENT

Select a Location

Call Us Text Us
Skip to content