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The Impact of Weight Loss on Prostate Cancer Progression during Active Surveillance

In the realm of prostate cancer management, particularly for those on active surveillance, maintaining an optimal weight emerges as a potential factor influencing prognosis. Let’s explores the correlation between weight management and the progression of low-grade prostate cancer during active surveillance.

Understanding Active Surveillance

Upon receiving a diagnosis of low-grade prostate cancer, characterized by its confinement to the prostate gland and limited growth or spread potential, individuals often opt for active surveillance. This involves regular follow-ups, including PSA tests, prostate biopsies, and potentially MRI scans. Treatment, such as radiation or surgery, is considered if there are signs of cancer progression.

The Dynamics of Monitoring

For those on active surveillance, the primary focus is not necessarily on the transformation of the original low-grade cancer into a more aggressive form over time. Instead, the emphasis lies on detecting any high- or medium-grade cancer that might have been overlooked during the initial biopsy. While a significant percentage of individuals on active surveillance may not require treatment over a decade or more, uncertainties remain, necessitating ongoing vigilance.

Controlling Contributing Factors

While genetics and family history are beyond one’s control in influencing cancer progression, weight management emerges as a modifiable factor. Research indicates a noteworthy association between men who are overweight or obese and an increased risk of developing aggressive prostate cancer. Maintaining a healthy BMI and waist size may reduce risk of fatal prostate cancer.

Scientific Findings

Studies reveal a compelling connection between excess weight gain, especially around the abdominal area, and an elevated risk of advanced prostate cancer. A consistent yearly weight gain, as demonstrated by research, may further increase the likelihood of aggressive prostate cancer later in life.

The Weight-Cancer Nexus

While the precise mechanisms linking excess weight to prostate cancer growth are not fully understood, hypotheses suggest that inflammation and elevated blood sugar levels may play significant roles. Higher insulin levels, often associated with overweight and obesity, could potentially contribute to a more aggressive cancer profile.

Weight Loss as a Strategy

Considering the potential impact of weight on cancer progression, adopting a proactive approach towards weight loss becomes a plausible strategy. Incorporating a plant-based diet and increased physical activity aids in weight management but also reduces heart disease risk and risk of certain cancers.


In the realm of prostate cancer, particularly for those on active surveillance, recognizing the role of weight management in influencing cancer progression is crucial. While uncertainties persist, embracing a healthy lifestyle focusing on weight loss may contribute to a more favorable prognosis, allowing individuals to enhance their overall health during active surveillance.


Dr. David Samadi is the Director of Men’s Health and Urologic Oncology at St. Francis Hospital in Long Island. He’s a renowned and highly successful board certified Urologic Oncologist Expert and Robotic Surgeon in New York City, regarded as one of the leading prostate surgeons in the U.S., with a vast expertise in prostate cancer treatment and Robotic-Assisted Laparoscopic Prostatectomy.  Dr. Samadi is a medical contributor to NewsMax TV and is also the author of The Ultimate MANual, Dr. Samadi’s Guide to Men’s Health and Wellness, available online both on Amazon and Barnes & Noble. Visit Dr. Samadi’s websites at robotic oncolo gy and prostate cancer 911. 



Dr. David Samadi | Robotic Prostate Surgeon

About is a resource created by Dr. David Samadi in order to raise awareness and get more men to receive prostate cancer treatment. The information is strictly general and you should always discuss with your doctor issues concerning your health.


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